2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108398AS
    Mead acid-d6 2692624-12-5 98%
    Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
    Mead acid-d6
  • HY-108398BR
    11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard) 17046-59-2
    Isobutamben (Standard) is the analytical standard of Isobutamben. This product is intended for research and analytical applications. Isobutamben is a local anaesthetic.
    11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard)
  • HY-109120S1
    Odevixibat-13C6 98%
    Odevixibat-13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis.
    Odevixibat-13C6
  • HY-111095BR
    D-(-)-Lactic acid sodium (Standard) 920-49-0 98%
    D-(-)-Lactic acid ((R)-2-Hydroxypropionic acid) sodium (Standard) is the analytical standard of Malvidin-3-glucoside sodium. This product is intended for research and analytical applications. D-(-)-Lactic acid sodium is an orally active, toxic optical isomer of Lactic acid (HY-B2227), mainly derived from overproduction by intestinal bacteria or exogenous intake. D-(-)-Lactic acid sodium can induce intoxication, characterized by severe metabolic acidosis accompanied by neurological symptoms.
    D-(-)-Lactic acid sodium (Standard)
  • HY-111614S1
    Melengestrol acetate-d2 98%
    Melengestrol acetate-d2 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate-d2
  • HY-113067S1
    Phytanic acid-d39 1965250-60-5
    Phytanic acid-d39 is the deuterium labeled Phytanic acid. Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease.
    Phytanic acid-d39
  • HY-113147AR
    L-Palmitoylcarnitine chloride (Standard) 18877-64-0 98%
    L-Palmitoylcarnitine (chloride) (Standard) is the analytical standard of L-Palmitoylcarnitine (chloride). This product is intended for research and analytical applications. L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
    L-Palmitoylcarnitine chloride (Standard)
  • HY-113221AS
    Isovalerylcarnitine-d3 chloride 98%
    Isovalerylcarnitine-d3 chloride is the deuterium labeled Isovalerylcarnitine chloride (HY-145542). Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk.
    Isovalerylcarnitine-d3 chloride
  • HY-113239S1
    rel-Hydroxycotinine-d3 159956-78-2 98%
    rel-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    rel-Hydroxycotinine-d3
  • HY-113239S2
    (Rac)-Hydroxycotinine-d3 2714435-80-8 98%
    (Rac)-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    (Rac)-Hydroxycotinine-d3
  • HY-113247S1
    Muconic acid-d4 1185239-59-1 98%
    trans-trans-Muconic acid-d4-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
    Muconic acid-d4
  • HY-113252S1
    2-Methoxyestrone-13C6 98%
    2-Methoxyestrone-13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
    2-Methoxyestrone-13C6
  • HY-113261S1
    Oleoylcarnitine-13C,d3
    Oleoylcarnitine-13C,d3 is the deuterium and 13C-labeled Oleoylcarnitine (HY-113261). Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
    Oleoylcarnitine-13C,d3
  • HY-113263S1
    17α-Hydroxypregnenolone-13C2,d2 2483824-29-7 98%
    17α-Hydroxypregnenolone-13C2,d2 is the deuterium and 13C labeled 17α-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD).
    17α-Hydroxypregnenolone-13C2,d2
  • HY-113293BS
    Estrone sulfate-d5 sodium 2734919-86-7 98%
    Estrone sulfate-d5 sodium is the deuterium labeled Estrone sulfate sodium (HY-113293B). Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research.
    Estrone sulfate-d5 sodium
  • HY-113293S1
    Estrone sulfate-d4 TEA
    Estrone sulfate-d4 TEA is the deuterium labeled Estrone sulfate TEA. Estrone sulfate is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate is also a substrate of the OATP1B3 transporter. Estrone sulfate can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate is applicable to breast cancer-related research.
    Estrone sulfate-d4 TEA
  • HY-113295S3
    Salicyluric acid-d4 98%
    Salicyluric acid-d4 is deuterated labeled Salicyluric acid (HY-113295). Salicyluric acid is an endogenous metabolite.
    Salicyluric acid-d4
  • HY-113344S2
    16α-Hydroxyestrone-d3
    16α-Hydroxyestrone-d3 (16αOHE-d3) is the deuterium labeled 16α-Hydroxyestrone (HY-113344). 16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease.
    16α-Hydroxyestrone-d3
  • HY-113365S3
    Cholestenone-d7 2389048-48-8 98%
    Cholestenone-d7 is deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop
    Cholestenone-d7
  • HY-113367S1
    Suberylglycine-d2 1219799-02-6 98%
    Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
    Suberylglycine-d2
Cat. No. Product Name / Synonyms Application Reactivity